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European Journal of Gynaecological Oncology  2015, Vol. 36 Issue (5): 529-532    DOI: 10.12892/ejgo2693.2015
Original Research Previous articles | Next articles
Stage IVB endometrial cancer: clinical course and survival of patients with single and multiple metastases
O. Kraemer1, E. Rapiti2, D. Huber1, *(), E. Lopes-Raimundo3, M. Usel2, C. Bouchardy2, P. Petignat1
1Surgical Gynecologic Oncology Unit, Gynecologic Division, Geneva University Hospital, Geneva
2Geneva Cancer Registry, University of Geneva, Geneva 3 Faculty of Medicine, University of Geneva, Geneva (Switzerland)
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Objective: Metastatic endometrial cancer (EC) at initial presentation is a rare disease. The present aim was to evaluate prognostic factors and overall survival in patients diagnosed with metastatic EC. Study Design: Using data from the Geneva Cancer Registry, the authors included all patients diagnosed with Stage IVB EC from 1980-2007. Estimates of survival were calculated using the Kaplan-Meier method and compared using the log-rank test. Results: A total of 38 patients were identified. The most frequent metastases were peritoneal or pleural carcinomatosis (66%, n=25) and hematogenous metastases (53%, n=20). Five-year survival rate was 5.7% (95% confidence interval: 0.0 - 13.3), and median survival was 7.6 months. Survival of patients with a single metastasis at the time of diagnosis was longer than for patients with multiple metastases (16 versus two months, respectively; p < 0.001). Conclusion: Metastatic EC is rare disease with very poor prognosis particularly for patients with multiple site metastases.
Key words:  Advanced endometrial cancer      Metastatic endometrial cancer      Stage IVB endometrial cancer     
Published:  10 October 2015     
*Corresponding Author(s):  D. HUBER     E-mail:

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O. Kraemer, E. Rapiti, D. Huber, E. Lopes-Raimundo, M. Usel, C. Bouchardy, P. Petignat. Stage IVB endometrial cancer: clinical course and survival of patients with single and multiple metastases. European Journal of Gynaecological Oncology, 2015, 36(5): 529-532.

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[1] D. Akdag Cirik, A. Karalok, I. Ureyen, T. Tasci, S. Koc, T. Turan, G. Tulunay. Stage IVB endometrial cancer confined to the abdomen: Is chemotherapy superior to radiotherapy?[J]. European Journal of Gynaecological Oncology, 2016, 37(2): 226-231.
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