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European Journal of Gynaecological Oncology  2017, Vol. 38 Issue (2): 282-285    DOI: 10.12892/ejgo3377.2017
Original Research Previous articles | Next articles
The role of oxidative stress in premalignant lesions
G. Batmaz1, *(), E. Kılıç 2, P. Özcan1, E.A. Sarıoğlu1, N. Karaca1, B. Dane1
1 Bezmialem Vakif University, Department of Obstetrics and Gynecology Istanbul, Turkey
2 Bezmialem Vakif University, Deparment of Medical Biochemistry, Istanbul, Turkey
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Purpose of Investigation: The authors aimed to evaluate serum total oxidant status (TOS), total antioxidant status (TAS), and oxidative stress index (OSI) in women with abnormal cervical cytology, to determine the association between serum oxidant and antioxidant status of these women, and the progression of abnormal cervical cytology. Materials and Methods: A total of 75 women enrolled in the study: 20 women with a determination of atypical squamous cells of undetermined significance (ASCUS), 20 women with low squamous intraepithelial lesions (LSIL), 15 women with high squamous intraepithelial lesions (HSIL) and 20 healthy controls. Serum TOS and TAS were determined and OSI was calculated as the indicator of degree of oxidative stress. Results: Serum TOS levels and OSI were highest in the HSIL group and there was a trend toward increasing serum TOS levels and OSI from ASCUS to HSIL group. Conclusion: The authors demonstrated that increased oxidative stress with altered antioxidant level is associated with abnormal cervical cytology. Serum oxidant and antioxidant status may provide guidance as a simple and cost-effective method for follow-up, treatment, and recommendation in all stages of lesions.
Key words:  Total oxidant stress      Premalignant lesions      Abnormal cervical cytology     
Published:  10 April 2017     
*Corresponding Author(s):  G. BATMAZ     E-mail:

Cite this article: 

G. Batmaz, E. Kılıç, P. Özcan, E.A. Sarıoğlu, N. Karaca, B. Dane. The role of oxidative stress in premalignant lesions. European Journal of Gynaecological Oncology, 2017, 38(2): 282-285.

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