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European Journal of Gynaecological Oncology  2017, Vol. 38 Issue (3): 342-345    DOI: 10.12892/ejgo3436.2017
Original Research Previous articles | Next articles
A preliminary study for the treatment of cervical colposcopic lesions with the biological compound AV2
G. Martinez1, B.A. Mutombo2, *(), V. Fernandez1, J.P. Van Geertruyden3, Y. Jacquemyn4
1 Hospital de la Familia, Juarez, Mexico
2 University of Kinshasa, Department of Obstetrics and Gynecology, Kinshasa, Democratic Republic of the Congo
3 University of Antwerp, International Health Unit, Antwerp, Belgium
4 University of Antwerp, Department of Obstetrics and Gynecology, Antwerp, Belgium
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Abstract  
Objective: To evaluate the efficacy of AntiViral 2 (AV2) in the regression of moderate and severe colposcopic lesions, when compared to placebo. Materials and Methods: Women, aged over 18 years with a colposcopic diagnosis of moderate to severe dysplasia were randomized to receive either two applications of AV2 or placebo within four days. Both examining physician and patients were blinded to the treatment option. Follow-up colposcopy was performed on days 11, 21, and 60. Results: A total of 50 patients were enrolled in this study. There was no statistically significant difference in screening entry criteria between the two groups. The results showed that the application of AV2 yielded a reduction of more than 50% for 21 out of 28 (75%) patients who received the active treatment versus a 0% for the comparable placebo group (p < 0.001). Conclusions: The authors conclude that AV2 can have a place in the treatment of colposcopically-detected cervical lesions. Due to the proven broad spectrum antiviral activity of AV2, a plausible explanation is that the lesions regress due to deactivation of the virus. Further trials with larger numbers and detailed cytology and histology are needed to confirm these results.
Key words:  Cervical lesion      Colposcopy      Human papillomavirus      AV2      Essential oil      Treatment     
Published:  10 June 2017     
*Corresponding Author(s):  B.A. MUTOMBO     E-mail:  alexmutombo@gmail.com

Cite this article: 

G. Martinez, B.A. Mutombo, V. Fernandez, J.P. Van Geertruyden, Y. Jacquemyn. A preliminary study for the treatment of cervical colposcopic lesions with the biological compound AV2. European Journal of Gynaecological Oncology, 2017, 38(3): 342-345.

URL: 

https://ejgo.imrpress.com/EN/10.12892/ejgo3436.2017     OR     https://ejgo.imrpress.com/EN/Y2017/V38/I3/342

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