Please wait a minute...
European Journal of Gynaecological Oncology  2018, Vol. 39 Issue (4): 533-537    DOI: 10.12892/ejgo3857.2018
Original Research Previous articles | Next articles
Expression of Jun activation domain-binding protein 1 and p27 Kip1 in endometrial polyps and uterine leiomyomas
Arum Lee1, Tae-Hee Kim2, *(), Hae-Hyeog Lee2, Jun-Mo Kim3, Yeon-Suk Kim1
1 Department of Interdisciplinary Program in Biomedical Science, Soonchunhyang University Graduate School, Asan, Republic of Korea
2 Department of Obstetrics and Gynecology, Soonchunhyang University College of Medicine, Bucheon, Republic of Korea
3 Department of Urology, Soonchunhyang University College of Medicine, Bucheon, Republic of Korea
Download:  PDF
Export:  BibTeX | EndNote (RIS)      
Abstract  
Aim: The expression, localization, and density of Jab1 and p27 in endometrial polyps and uterine leiomyomas and the associations between these diseases and Jab1 and p27 based on clinical outcomes were explored. Materials and Methods: Tissues from 28 patients (14 with endometrial polyps and 14 with uterine leiomyomas) were used to investigate the expression of Jab1 and p27 by immunohistochemical analysis from November 2011 to April 2014. Results: Jab1 exhibited positive immunoreactivity: 78.5% in the endometrial polyp group in glandular epithelial cells and 71.4% in the uterine leiomyoma group in smooth muscle cells. In contrast to Jab1, p27 exhibited negative immunoreactivity: 76.9% in the endometrial polyp group and 78.6% in the uterine leiomyoma group. The lesions were larger in cases of expressed Jab1 only, rather than in cases with positive or negative expression of both proteins. Tissues that were recurrent did not express p27. Conclusions: Jab1 was expressed in the glandular epithelium of endometrial polyps and stromal layer of uterine leiomyomas, while p27 was suppressed in both diseases. Positive expression of Jab1 and negative expression of p27 were related to lesion growth.
Key words:  Endometrium      Jab1      Leiomyoma      Polyps      Proteins      Uterus     
Published:  10 August 2018     
*Corresponding Author(s):  TAE-HEE KIM     E-mail:  heeobgy@naver.com

Cite this article: 

Arum Lee, Tae-Hee Kim, Hae-Hyeog Lee, Jun-Mo Kim, Yeon-Suk Kim. Expression of Jun activation domain-binding protein 1 and p27 Kip1 in endometrial polyps and uterine leiomyomas. European Journal of Gynaecological Oncology, 2018, 39(4): 533-537.

URL: 

https://ejgo.imrpress.com/EN/10.12892/ejgo3857.2018     OR     https://ejgo.imrpress.com/EN/Y2018/V39/I4/533

[1] Joseph J. Noh, Sir-Yeon Hong, Byeong-gie Kim. Malignant perivascular epithelioid cell tumor (PEComa) of uterus: A case report with literature review[J]. European Journal of Gynaecological Oncology, 2020, 41(4): 495-499.
[2] Chiharu Mizoguchi, Harunobu Matsumoto, Kaei Nasu, Kentaro Kai, Motoki Arakane, Hisashi Narahara. Collision tumour of endometrial stromal sarcoma, uterine tumour resembling ovarian sex-cord tumour, and leiomyoma[J]. European Journal of Gynaecological Oncology, 2020, 41(4): 634-637.
[3] Terumi Tanigawa, Maki Matoda, Yoichi Aoki, Hidetaka Nomura, Sanshiro Okamoto, Kohei Omatsu, Hiroyuki Kanao, Nobuhiro Takeshima. A case of recurrent smooth muscle tumor of uncertain malignant potential with abdominal dissemination after morcellation[J]. European Journal of Gynaecological Oncology, 2020, 41(4): 648-650.
[4] Marcin Jedryka, Agnieszka Chrobak, Anna Chelmonska-Soyta, Daria Fijalkowska, Rafal Matkowski. Decreased expression of estrogen receptors alpha and beta in peripheral blood lymphocytes from the endometrial cancer patients and women with endometriosis[J]. European Journal of Gynaecological Oncology, 2020, 41(3): 375-379.
[5] J. H. Sang, J. I. Choi, S.-H. Chung. Case series of uterine smooth muscle tumors of uncertain malignant potential (STUMP)[J]. European Journal of Gynaecological Oncology, 2020, 41(3): 492-494.
[6] H. Cokmez, A. Yilmaz. Concordance of preoperative and postoperative histological grades in endometrioid type endometrial cancer[J]. European Journal of Gynaecological Oncology, 2020, 41(2): 208-213.
[7] Sang Wook Yi. Malignant mixed mesonephric tumor arising in mesonephric carcinoma: a case report with complete remission after concurrent chemoradiation therapy[J]. European Journal of Gynaecological Oncology, 2020, 41(2): 320-322.
[8] R. Tasaka, Y. Hashiguchi, M. Kasai, T. Fukuda, T. Ichimura, T. Yasui, T. Sumi. Secondary small cell carcinoma of the endometrium after concurrent chemoradiotherapy for cervical cancer: a rare case[J]. European Journal of Gynaecological Oncology, 2020, 41(1): 142-144.
[9] N. Okabe, M. Fujiwara, M. Mochizuki, K. Ohtsuka, Y. Nishigaya, Y. Kobayashi, H. Kamma. CD34-positive uterine lipoleiomyoma in a postmenopausal woman with chronic glomerulonephritis[J]. European Journal of Gynaecological Oncology, 2019, 40(6): 1060-1063.
[10] A.C. da Silva, T. Calapodopulos, T.C. Guaresqui, J. C. Saldanha, E.F.C. Murta, R.S. Nomelini. Uterine smooth muscle tumor of uncertain malignant potential[J]. European Journal of Gynaecological Oncology, 2019, 40(6): 1070-1072.
[11] H. Ibrahim, K. Dresser, K. M. Cornejo. Loss of 5-hydroxymethylcytosine (5-hmC) expression in endometrioid type endometrial carcinoma[J]. European Journal of Gynaecological Oncology, 2019, 40(5): 846-848.
[12] T. Tomimatsu, S. Mabuchi, T. Tsuboyama, Y. Hori, S. Sekine, T. Kimura. Malignant transformation of uterine leiomyoma: suggested by clinical, imaging, histological, and genetic findings[J]. European Journal of Gynaecological Oncology, 2019, 40(5): 879-882.
[13] Dong-Hee Kim, Seung-Do Choi, Hae-Hyeog Lee, Tae-Hee Kim, Yeon-Suk Kim, Yesol Kim. The role of vitamin D up-regulated protein 1 in epithelial ovarian cancer[J]. European Journal of Gynaecological Oncology, 2019, 40(4): 585-592.
[14] A. Mladěnka, P. Mladěnka, O. Simetka, J. Klát. Intra-operative and postoperative complications depend on operating approach and body mass index in patients with malignant uterus body neoplasm[J]. European Journal of Gynaecological Oncology, 2019, 40(4): 593-598.
[15] X. Lyu, P. Liu, H. Mao, B. Han, X. Wei. Small cell carcinoma of the endometrium mixed with endometriod adenocarcinoma: a case report[J]. European Journal of Gynaecological Oncology, 2019, 40(4): 676-678.
No Suggested Reading articles found!