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European Journal of Gynaecological Oncology  2018, Vol. 39 Issue (6): 921-925    DOI: 10.12892/ejgo4009.2018
Original Research Previous articles | Next articles
Correlation between the intrinsic subtype and diagnostic methods of axillary lymph node metastasis in primary breast cancer
Yu Feng1, Yunchao Wang1, Xia Zhao1, Ying Mu1, Shuzhen Lv1, Yanping Li1, *()
1 Breast Center, Beijing Shijitan Hospital, Captial Medical University, Beijing, China
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Abstract  
Objectives: To discover the relationship between intrinsic subtypes and axillary lymph nodes metastatic proportion, to compare the accuracy of clinical examination, ultrasound-guided fine-needle aspiration cytology of suspicious axillary nodes, and to evaluate the best method of axillary lymph nodes staging in patients with breast cancer. Materials and Methods: From May 2010 to March 2015, patients presenting with primary breast cancer had clinical examination and ultrasonography for axillary lymph node staging. The pathological results of US-guided needle biopsy and clinical data of these patients were collected and analyzed retrospectively. Results: A total of 292 (41.8%) of 698 patients confirmed the presence of axillary lymph nodes metastases. Luminal B (HER2-) and HER2 positive tumors had a higher node positivity rate than other intrinsic types. Axillary lymph nodes metastases rate indicates significant difference in each intrinsic subtype. Sixty-eight (11.5%) node-positive patients were identified by ultrasound-fine needle aspiration cytology (BUS–FNAC) and spared unnecessary sentinel lymph node biopsy (SLNB). Fifteen (14.2%) patients who had palpable lymph nodes had negative results in both FNAC and SLNB, and spared unnecessary complete axillary node clearance. Clinical examination had an accuracy of 69.1%, and EBUS-FNAC had 79.4%. Conclusion: The intrinsic subtypes are related with axillary lymph node metastasis in primary breast cancer. In comparing with clinical examination, ultrasonography evaluation for axilla status, combined with ultrasoundguided needle biopsy of suspicious axillary node is more accurate, and it is valuable prior to SLNB in primary breast cancer treatment.
Key words:  Breast cancer      Intrinsic subtypes      Lymph node      Fine-needle aspiration cytology      prognosis      treatment     
Published:  10 December 2018     
*Corresponding Author(s):  YANPING LI     E-mail:  lyp671102@sina.com

Cite this article: 

Yu Feng, Yunchao Wang, Xia Zhao, Ying Mu, Shuzhen Lv, Yanping Li. Correlation between the intrinsic subtype and diagnostic methods of axillary lymph node metastasis in primary breast cancer. European Journal of Gynaecological Oncology, 2018, 39(6): 921-925.

URL: 

https://ejgo.imrpress.com/EN/10.12892/ejgo4009.2018     OR     https://ejgo.imrpress.com/EN/Y2018/V39/I6/921

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