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| Human papillomavirus prevalence and breast carcinogenesis: a systematic review and meta-analysis of published literature |
K. Favere1, S. Menon2, K. Valentine2, J. Bogers3, 4, 5, D. Vanden Broeck3, 4, 5, *( ) |
1 Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium
2 International Centre for Reproductive Health, Ghent University, Ghent, Belgium
3 Applied Molecular Biology Research Group, University of Antwerp, Antwerp, Belgium
4 AML-Molecular Diagnostics, Antwerp, Belgium
5 International Centre for Reproductive Health, Ghent University, Ghent, Belgium |
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Abstract
Purpose of investigation: The association between human papillomavirus (HPV) infection and breast cancer remains inconclusive as detection rates of high-risk HPV in breast cancer samples are extremely variable. A meta-analysis was conducted to determine the prevalence of HPV in breast neoplasms, with emphasis on genotype distribution. Materials and Methods: A systematic literature search of MEDLINE, The Cochrane Library, and ISI Web of Science databases was conducted, ending in August 2016. A meta-analysis was performed applying the random-effects model. Sub-analyses allowed to estimate the impact of different variables on the pooled prevalence. Results: Forty studies, representing 4762 breast cancer cases, were included. The pooled prevalence of HPV in breast cancer tissue was 20% (95% confidence interval (CI) [12%;29%]). HPV prevalence in breast neoplasms varied by publication period, continental region, HPV primer design, and HPV oncogenic features. Continental region of origin determined the prevailing genotype. Conclusion: The high prevalence of HPV in breast cancer supports the hypothesis that HPV infection is involved in breast carcinogenesis.
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Published: 10 April 2018
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*Corresponding Author(s):
D.VANDEN BROECK
E-mail: davy.vandenbroeck@ugent.be
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2018, Vol. 39 
