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European Journal of Gynaecological Oncology  2018, Vol. 39 Issue (2): 161-173    DOI: 10.12892/ejgo4068.2018
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Human papillomavirus prevalence and breast carcinogenesis: a systematic review and meta-analysis of published literature
K. Favere1, S. Menon2, K. Valentine2, J. Bogers3, 4, 5, D. Vanden Broeck3, 4, 5, *()
1 Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium
2 International Centre for Reproductive Health, Ghent University, Ghent, Belgium
3 Applied Molecular Biology Research Group, University of Antwerp, Antwerp, Belgium
4 AML-Molecular Diagnostics, Antwerp, Belgium
5 International Centre for Reproductive Health, Ghent University, Ghent, Belgium
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Abstract  
Purpose of investigation: The association between human papillomavirus (HPV) infection and breast cancer remains inconclusive as detection rates of high-risk HPV in breast cancer samples are extremely variable. A meta-analysis was conducted to determine the prevalence of HPV in breast neoplasms, with emphasis on genotype distribution. Materials and Methods: A systematic literature search of MEDLINE, The Cochrane Library, and ISI Web of Science databases was conducted, ending in August 2016. A meta-analysis was performed applying the random-effects model. Sub-analyses allowed to estimate the impact of different variables on the pooled prevalence. Results: Forty studies, representing 4762 breast cancer cases, were included. The pooled prevalence of HPV in breast cancer tissue was 20% (95% confidence interval (CI) [12%;29%]). HPV prevalence in breast neoplasms varied by publication period, continental region, HPV primer design, and HPV oncogenic features. Continental region of origin determined the prevailing genotype. Conclusion: The high prevalence of HPV in breast cancer supports the hypothesis that HPV infection is involved in breast carcinogenesis.
Key words:  Breast neoplasms      Review      Meta-analysis      Epidemiology      Etiology      Papillomaviridae     
Published:  10 April 2018     
*Corresponding Author(s):  D.VANDEN BROECK     E-mail:  davy.vandenbroeck@ugent.be

Cite this article: 

K. Favere, S. Menon, K. Valentine, J. Bogers, D. Vanden Broeck. Human papillomavirus prevalence and breast carcinogenesis: a systematic review and meta-analysis of published literature. European Journal of Gynaecological Oncology, 2018, 39(2): 161-173.

URL: 

https://ejgo.imrpress.com/EN/10.12892/ejgo4068.2018     OR     https://ejgo.imrpress.com/EN/Y2018/V39/I2/161

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