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European Journal of Gynaecological Oncology  2019, Vol. 40 Issue (5): 879-882    DOI: 10.12892/ejgo4633.2019
Case Report Previous articles | Next articles
Malignant transformation of uterine leiomyoma: suggested by clinical, imaging, histological, and genetic findings
T. Tomimatsu1, *(), S. Mabuchi1, T. Tsuboyama2, Y. Hori3, S. Sekine4, T. Kimura1
1Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka, Japan
2Department of Radiology, Osaka University Graduate School of Medicine, Osaka, Japan
3Department of Pathology, Osaka University Graduate School of Medicine, Osaka, Japan
4Division of Molecular Pathology, National Cancer Center Research Institute, Tokyo, Japan
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Abstract  

The authors describe a case of uterine leiomyosarcoma, in which clinical, radiological, histopathological, and genetic findings suggested malignant transformation of uterine leiomyoma as the cause of the disease. A 37-year-old woman receiving follow-up care for a uterine leiomyoma detected six years ago presented with lower abdominal pain. Sequential magnetic resonance imaging scans indicated the development of uterine leiomyosarcoma in the same location as the preexisting uterine leiomyoma. Histopathological examination of the excised tumor revealed uterine leiomyosarcoma with a component of uterine leiomyoma. Concordant mediator subcomplex 12 gene mutation status was observed in both components. This report supports the possibility of malignant transformation of uterine leiomyoma to uterine leiomyosarcoma.

Key words:  Malignant transformation      Uterine leiomyoma      Uterine leiomyosarcoma     
Published:  10 October 2019     
*Corresponding Author(s):  T. TOMIMATSU     E-mail:  tomimatsu@gyne.med.osaka-u.ac.jp

Cite this article: 

T. Tomimatsu, S. Mabuchi, T. Tsuboyama, Y. Hori, S. Sekine, T. Kimura. Malignant transformation of uterine leiomyoma: suggested by clinical, imaging, histological, and genetic findings. European Journal of Gynaecological Oncology, 2019, 40(5): 879-882.

URL: 

https://ejgo.imrpress.com/EN/10.12892/ejgo4633.2019     OR     https://ejgo.imrpress.com/EN/Y2019/V40/I5/879

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