Please wait a minute...
European Journal of Gynaecological Oncology  2019, Vol. 40 Issue (6): 925-931    DOI: 10.12892/ejgo4993.2019
Original Research Previous articles | Next articles
Association between miR-124 rs531564 and miR-100 rs1834306 polymorphisms and cervical cancer: a meta-analysis
H. Shang1, L. Sun1, T. Braun2, Q. Si1, J. Tong1, *()
1Department of Obstetrics and Gynecology, The Affiliated Hangzhou First People’s Hospital, zhejiang University School of Medicine, Hangzhou, zhejiang Province, China
2Department of Obstetrics and Gynecology, Charite Medical University, Berlin, Germany
Download:  PDF(2120KB)  ( 116 ) Full text   ( 3 )
Export:  BibTeX | EndNote (RIS)      
Abstract  

Aim: To explore the correlations between miR-124 rs531564 and miR-100 rs1834306 polymorphisms and cervical cancer (CC). Materials and Methods: Relevant studies were searched from the electronic databases Embase, Cochrane library, and PubMed updated to January 2017, as well as through literature tracing. Studies were selected based on strict criteria, followed by the included studies which were conducted with quality assessment using Newcastle-Ottawa Scale (NOS). With odds ratios (ORs) and corresponding 95% confidence intervals (95% CIs) as effect indicators, meta-analysis for exploring the correlations between rs531564 and rs1834306 polymorphisms and CC was performed using R 3.12 software. Using Egger’s test, publication bias was elevated for the included studies. In addition, sensitivity analysis was carried out. Results: There were a total of four eligible studies, involving 3,707 participators (including 1,592 CC patients and 2,115 healthy controls). The NOS scores of the included studies were 5-7, indicating a high quality. Meta-analysis showed that all genetic models of rs531564 were statistically significant (p < 0.05), indicating that rs531564 was associated with the occurrence of CC. Nevertheless, the situation for rs1834306 was exactly the opposite. Egger’s test for rs531564 showed no publication bias, suggesting that our results were reliable. Sensitivity analysis showed that the pooled results of rs531564 were stable in general. Conclusion: These indicated that rs531564 was correlated with the development of CC, but not rs1834306.

Key words:  Cervical cancer      microRNAs      rs531564      rs1834306      Meta-analysis     
Published:  10 December 2019     
*Corresponding Author(s):  J. TONG     E-mail:  huixin965zhangqiao@163.com

Cite this article: 

H. Shang, L. Sun, T. Braun, Q. Si, J. Tong. Association between miR-124 rs531564 and miR-100 rs1834306 polymorphisms and cervical cancer: a meta-analysis. European Journal of Gynaecological Oncology, 2019, 40(6): 925-931.

URL: 

https://ejgo.imrpress.com/EN/10.12892/ejgo4993.2019     OR     https://ejgo.imrpress.com/EN/Y2019/V40/I6/925

[1] Eda Kucuktulu, Ahmet Fatih Yurekli. Simultaneous Integrated Intensity Modulated Radiotherapy Boost for Gynecological Cancer when Brachytherapy is not an Option[J]. European Journal of Gynaecological Oncology, 2020, 41(5): 720-725.
[2] Wook Youn Kim, Shin Hee Seo, Seung-Hyuk Shim, Jin Hee Park, Hyung Kyu Park, Kyeong A So, Tae Jin Kim, Sun Joo Lee. Correlation of immunohistochemistry and silver in situ hybridization for the assessment of c-MET in uterine cervical cancer patients treated with radical hysterectomy[J]. European Journal of Gynaecological Oncology, 2020, 41(5): 745-752.
[3] John P. Micha, Howard D. Epstein, Michael C. Roossin, Randy Bohart, Mark A. Rettenmaier, Bram H. Goldstein. Neoadjuvant chemotherapy, radical hysterectomy and chemoradiation for stage iva cervical carcinoma[J]. European Journal of Gynaecological Oncology, 2020, 41(5): 797-801.
[4] Juan Xu, Qingqing Tan, Ting Li. USP22 promotes the expression of GLUT1 and HK2 to facilitate growth and glycolysis in cervical cancer cells[J]. European Journal of Gynaecological Oncology, 2020, 41(5): 790-796.
[5] Yan qin Zhang, Di Wu, Meng qi Deng, Xiang yu Chang, Jin wei Miao, Yu mei Wu. Individual management of cervical cancer during pregnancy[J]. European Journal of Gynaecological Oncology, 2020, 41(5): 833-837.
[6] Yi-fan Luo, Li-xiang Ren, Ming-yan Jiang, Yang Chu. A systematic review and meta-analysis on the effects of metformin on survival outcomes and risk in women with cervical cancer[J]. European Journal of Gynaecological Oncology, 2020, 41(4): 504-507.
[7] Liman Yang, Jing Jin, Juhong Liu. Correlation of MMP2-C1306T (rs243865) and MMP7-181A/G (rs11568818) with cervical cancer: a meta-analysis[J]. European Journal of Gynaecological Oncology, 2020, 41(4): 508-512.
[8] Panteleimon Mnimatidis, Abraham Pouliakis, George Valasoulis, George Michail, Aris Spathis, Christine Cottaridi, Niki Margari, Maria Kyrgiou, Maria Nasioutziki, Alexandros Daponte, Konstantinos Dinas, Evangelos Paraskevaidis, Ioannis Panayiotides, Dimitrios-Dionysios Koutsouris. Multicentric assessment of cervical HPV infection co-factors in a large cohort of Greek women[J]. European Journal of Gynaecological Oncology, 2020, 41(4): 545-555.
[9] Fengmei Wang , Huachun Luo , Huihua Cheng, Huijuan Huang , Zhichao Fu. Is 3D printing-gided three-dimensional brachytherapy suitable for cervical cancer: from one single research institute?[J]. European Journal of Gynaecological Oncology, 2020, 41(4): 591-597.
[10] Hiroshi Yoshida, Megumi Yamamoto, Hiroyuki Shigeta. Successful treatment of uterine cervical carcinoma with extensive vaginal lesions using laparoscopic surgery: A case report[J]. European Journal of Gynaecological Oncology, 2020, 41(4): 629-633.
[11] Hikari Unno, Seiji Mabuchi, Isao Arai, Tomoko Wakasa, Seiichi Yamamasu. Development of lymphangiosarcoma after pelvic radiation therapy for uterine cervical cancer: A case report and literature review[J]. European Journal of Gynaecological Oncology, 2020, 41(3): 326-331.
[12] B.-H. Zhang, L. Li, J. Ji, J. Guo, X.-L. Zhou, H. Xu, F. Cao, X.-H. Tong. Prognostic value of Foxp3+ regulatory T cells in endometrial cancer: a meta-analysis[J]. European Journal of Gynaecological Oncology, 2020, 41(3): 339-342.
[13] L. Xu, H. Cai, N. Zhu, Bo Zheng. Interleukin-22 derived from cervical cancer-associated fibroblasts accelerates senescence of normal fibroblasts and promotes expression of tumorigenesis-related factors in HeLa cells[J]. European Journal of Gynaecological Oncology, 2020, 41(2): 192-199.
[14] Hong Yan, Chunhua Zhang, Tingting Liu, Jianzhong Liu. Mifepristone regulates the multidrug resistance via miR-758/MEPE of Hela cell lines[J]. European Journal of Gynaecological Oncology, 2020, 41(2): 214-220.
[15] K. Plagens–Rotman, M. Piskorz–Szymendera, B. PIĘTA. Lifestyle with particular emphasis on physical activity and genital carcinomas in women[J]. European Journal of Gynaecological Oncology, 2020, 41(2): 233-239.
No Suggested Reading articles found!