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European Journal of Gynaecological Oncology  2019, Vol. 40 Issue (6): 1010-1018    DOI: 10.12892/ejgo5194.2019
Original Research Previous articles | Next articles
How safe is a three-year screening interval for cervical cancer with conventional cytology in southeastern Serbia?
R. Zivadinovic1, 5, *(), D. Stankovic-Djordjevic2, 8, B. Zivadinovic3, 6, D. Krtinic4, 7, A. Petric1, 5, A. Zivadinovic9, V. Radovanovic9
1Department for Gynecology and Obstetrics, Faculty of Medicine, University of Nis, Serbia
2Department for Microbiology and Immunology, Faculty of Medicine, University of Nis, Serbia
3Department for Neurology, Faculty of Medicine, University of Nis, Serbia
4Department for Pharmacology and Toxicology, Faculty of Medicine, University of Nis, Serbia
5Clinic for Gynecology and Obstetrics, Clinical center, Nis, Serbia
6Clinic for Neurology, Clinical center, Nis, Serbia
7Clinic for Oncology, Clinical center, Nis, Serbia
8Institute for Public Health, Nis, Serbia
9Faculty of Medicine, University of Nis, Nis, Serbia
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Abstract  

Aim: Purpose of this investigation was to determine the influence of cervical cytology on the reduction of high-grade cervical intraepithelial lesions (HSIL) and cervical cancer (CC) incidence. Materials and Methods: All the patients treated for HSIL and CC at the Clinic for Gynecology and Obstetrics Nis in the last three years. All filled in questionnaires. Before the surgery treatment, human papillomavirus (HPV) test samples were obtained from all the patients. Results: The results have shown that a three-year cervical cancer screening using conventional cytology is not reliable enough and it has not been shown to result in statistically significant reduction of HSIL and CC incidence. Conclusion: HPV test has increased the reliability of cytology in detecting pre-invasive lesions and it has statistically significantly reduced false-negative rate of cytology results in micro-invasive and invasive changes of the cervix.

Key words:  Conventional cytology      Human papillomavirus testing      Cervical cancer screening     
Published:  10 December 2019     
*Corresponding Author(s):  R. ZIVADINOVIC     E-mail:  radomir.zivadinovic@medfak.ni.ac.rs

Cite this article: 

R. Zivadinovic, D. Stankovic-Djordjevic, B. Zivadinovic, D. Krtinic, A. Petric, A. Zivadinovic, V. Radovanovic. How safe is a three-year screening interval for cervical cancer with conventional cytology in southeastern Serbia?. European Journal of Gynaecological Oncology, 2019, 40(6): 1010-1018.

URL: 

https://ejgo.imrpress.com/EN/10.12892/ejgo5194.2019     OR     https://ejgo.imrpress.com/EN/Y2019/V40/I6/1010

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[2] M. Ozturk, H. Umudum, A. Aydin, M. Ulubay, U. Keskin, M. Dede, M.C. Yenen. Immediate risk of HSIL presence in women who have both ASC-US cytology and negative high-risk HPV test[J]. European Journal of Gynaecological Oncology, 2016, 37(2): 232-237.
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