Please wait a minute...
European Journal of Gynaecological Oncology  2020, Vol. 41 Issue (3): 462-464    DOI: 10.31083/j.ejgo.2020.03.5048
Case Report Previous articles | Next articles
Preserving fertility in patients with granulosa cell tumors of the ovary
L. Nejković1, 2, J. Stulić1(), I. Rudić Biljić Erski1, A. Ristić1, 2, R. Aničić1, 2, M. Vasiljević1, 2
1Clinic of Obstetrics and Gynecology "Narodni Front", Belgrade, Serbia
2Medical Faculty, University of Belgrade, Belgrade, Serbia
Download:  PDF(646KB)  ( 413 ) Full text   ( 9 )
Export:  BibTeX | EndNote (RIS)      
Abstract  

Granulosa cell tumors of the ovary are rare ovarian neoplasms developing from ovarian stromal cells. They are characterized by insidious growth, low malignancy potential, and late recurrence. Due to the production of estrogen by these tumors, the frequent symptoms that occur in these patients develop as a result of hyperestrogenism. Standard treatment involves surgery in all patients. Fertility-sparing surgery is considered safe in young patients only in case of early-stage IA and IC tumors, where it is necessary to perform a unilateral salpingo-oophorectomy and complete staging. Surgical staging includes peritoneal washing, multiple peritoneal biopsies, omental biopsy, and biopsy of any suspicious area.

Key words:  Ovarian granulosa cell tumor      Fertility-sparing surgery in patients with granulosa cell tumors     
Submitted:  24 October 2018      Accepted:  07 January 2019      Published:  15 June 2020     
*Corresponding Author(s):  J. Stuli?     E-mail:  jstulicbgd@gmail.com

Cite this article: 

L. Nejković, J. Stulić, I. Rudić Biljić Erski, A. Ristić, R. Aničić, M. Vasiljević. Preserving fertility in patients with granulosa cell tumors of the ovary. European Journal of Gynaecological Oncology, 2020, 41(3): 462-464.

URL: 

https://ejgo.imrpress.com/EN/10.31083/j.ejgo.2020.03.5048     OR     https://ejgo.imrpress.com/EN/Y2020/V41/I3/462

[1] Aymen F.M., Majed G., Hanene C., Joumana L., Amin B.: “Advanced Granulosa Cell Tumor and Pregnancy: A Case Report, How to Treat and How to Preserve Fertility?”. Endocrinol Metab. Syndr., 2016, 5, 250.
[2] Manel Dridi, Nesrine Chraiet, Rim Batti, Mouna Ayadi, Amina Mokrani.: “Granulosa Cell Tumor of the Ovary: A Retrospective Study of 31 Cases and a Review of the Literature.International Journal of Surgical Oncology”. Int. J. Surg. Oncol., 2018, 2018, 4547892.
doi: 10.1155/2018/4547892 pmid: 29796312
[3] Vijaykumar Dehannathparambil Kottarathil, Michelle Aline Antony, Indu R. Nair, Keechilat Pavithran.: “Recent Advances in Granulosa Cell Tumor Ovary: A Review”. Indian J. Surg. Oncol., 2013, 4, 37.
doi: 10.1007/s13193-012-0201-z pmid: 24426698
[4] Divya Khosla, Kislay Dimri, Awadhesh K. Pandey, Rohit Mahajan, Romeeta Trehan.: “Ovarian Granulosa Cell Tumor: Clinical Features, Treatment, Outcome, and Prognostic Factors”. N. Am. J. Med. Sci., 2014, 6, 133.
doi: 10.4103/1947-2714.128475 pmid: 24741552
[5] Wang D., Cao D., Jia C., Huang H., Yang J., Wu M., et al.: “Analysis of oncologic and reproductive outcomes after fertility-sparing surgery in apparent stage I adult ovarian granulosa cell tumors”. Gynecol. Oncol., 2018, 151, 275.
doi: 10.1016/j.ygyno.2018.09.004 pmid: 30219238
[6] Homesley H.D., Bundy B.N., Hurteau J.A., Roth L.M.: “Bleomycin, etoposide, and cisplatin combination therapy of ovarian granulosa cell tumors and other stromal malignancies: A Gynecologic Oncology Group study”. Gynecol. Oncol., 1999, 72, 131.
doi: 10.1006/gyno.1998.5304 pmid: 10021290
[7] Schumer S.T., Cannistra S.A.: “Granulosa cell tumor of the ovary”. J. Clin. Oncol., 2003, 15, 1180.
[8] Kanthan R., Senger J.L., Kanthan S.: “The multifaceted granulosa cell tumours-myths and realities: A review”. ISRN Obstet. Gynecol., 2012, 2012, 878635.
doi: 10.5402/2012/878635 pmid: 23008780
[9] Zhang M., Cheung M.K., Shin J.Y., Kapp D.S., Husain A., Teng N.N., et al.: “Prognostic factors responsible for survival in sex cord stromal tumors of the ovary: an analysis of 376 women”. Gynecol. Oncol., 2007, 104, 396.
[10] Homesley H.D., Bundy B.N., Hurteau J.A., Roth L.M., “Bleomycin, etoposide, and cisplatin combination therapy of ovarian granulosa cell tumors and other stromal malignancies: A Gynecologic Oncology Group study”. Gynecol. Oncol., 1999, 72, 131.
pmid: 10021290
[11] Pautier P., Gutierrez Bonnaire M., Rey A., Sillet Bach I., Chevreau C., Kerbrat P., et al.: “Combination of bleomycin, etoposide, and cisplatin for the treatment of advanced ovarian granulosa cell tumors”. Int. J. Gynecol. Cancer., 2008, 18, 446.
doi: 10.1111/j.1525-1438.2007.01049.x pmid: 18494093
[12] Iavazzo C., Gkegkes I.D., Vrachnis N.: “Fertility sparing management and pregnancy in patients with granulosa cell tumour of the ovaries”. J. Obstet. Gynaecol., 2015, 35, 331.
doi: 10.3109/01443615.2014.968107 pmid: 25383508
No related articles found!
No Suggested Reading articles found!