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European Journal of Gynaecological Oncology  2020, Vol. 41 Issue (4): 545-555    DOI: 10.31083/j.ejgo.2020.04.5180
Original Research Previous articles | Next articles
Multicentric assessment of cervical HPV infection co-factors in a large cohort of Greek women
Panteleimon Mnimatidis1, *(), Abraham Pouliakis2, George Valasoulis3, George Michail4, Aris Spathis2, Christine Cottaridi2, Niki Margari5, Maria Kyrgiou6, 7, Maria Nasioutziki8, Alexandros Daponte9, Konstantinos Dinas8, Evangelos Paraskevaidis10, Ioannis Panayiotides2, Dimitrios-Dionysios Koutsouris1
1Biomedical Engineering Laboratory, National Technical University of Athens, Iroon Politechniou 9, 15780, Zografou, Athens, Greece
2Second Department of Pathology, National and Kapodistrian University of Athens, Attikon University Hospital, Rimini 1, 12464, Haidari, Athens, Greece
3Department of Obstetrics & Gynaecology, Health Center of Larisa, Roosevelt 4, 41222, Larisa, Greece
4Department of Obstetrics & Gynaecology, University Hospital of Patras, 26504, Rio, Patras, Greece
5Private Cytopathology Laboratory, Kifissias avenue 27A, 11523, Ampelokipi, Athens, Greece
6Institute of Reproductive and Developmental Biology, Department of Surgery and Cancer, Imperial College, Hammersmith Campus, Du Cane Road, W12 0NN, London, Great Britain
7West London Gynaecological Cancer Centre, Queen Charlotte’s and Chelsea - Hammersmith Hospital, Imperial Healthcare NHS Trust, Du Cane Road, W12 0HS, White City, London, Great Britain
82nd Department of Obstetrics & Gynecology and Molecular Clinical Cytology Laboratory, Hippokration Hospital, Aristotle University of Thessaloniki, Konstantinoupoleos 49, 54642, Thessaloniki, Greece
9Department of Obstetrics & Gynaecology, University Hospital of Larisa, Mezourlo, 41110, Larisa, Greece
10Department of Obstetrics & Gynaecology, University Hospital of Ioannina, Leof. Stavrou Niarchou 1, 45500, Ioannina, Greece
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Abstract  
Purpose of Investigation: Despite the general principle that persistent high risk human papillomavirus (hr-HPV) infection may progressively cause cervical cancer (CxCa), demographic aspects may still identify groups at high risk for HPV infection and consequently for precancerous lesions. The role of demographic parameters on cervical status, the diagnostic accuracy of cytology, HPV genotyping, and their possible combinations, were investigated in this study. Materials and Methods: 11,072 women from diverse locations across Greece participated in the study. Liquid Based Cytologic (LBC) assessment was followed, when necessary, by HPV-genotyping and histologic confirmation. Demographic characteristics were also assessed. Results: Life style parameters such as age, number of sexual partners, condom use, parity and marital status, education level, and combination of smoking/condom use, were significant factors for CIN2+ lesions (p < 0.05). For LSIL+ detection, cytology had maximum sensitivity: 96.90%, HPV-typing: 72.55% and co-testing: 98.97%, for HSIL+ detection: 98.49%, 92.22%, and 99.55% respectively. Conclusions: There are notable relationships between lifestyle, demographic details, and cervical status. Despite the differences in sensitivity and specificity levels, co-testing might offer some marginal improvement in the detection of particular pre-cancerous conditions.
Key words:  Cervical cancer      Biomarkers      Cervical cytology      Cervical intraepithelial neoplasia      HPV     
Submitted:  11 March 2018      Accepted:  05 June 2019      Published:  15 August 2020     
Fund: 
11ΣΥΝ_10_250/Project acronym: HPV-Guard
ATT 95/General Secretariat for Research and Technology (GSRT)
Greek Ministry of Health
*Corresponding Author(s):  PANTELEIMON MNIMATIDIS     E-mail:  pmnimati@yahoo.gr

Cite this article: 

Panteleimon Mnimatidis, Abraham Pouliakis, George Valasoulis, George Michail, Aris Spathis, Christine Cottaridi, Niki Margari, Maria Kyrgiou, Maria Nasioutziki, Alexandros Daponte, Konstantinos Dinas, Evangelos Paraskevaidis, Ioannis Panayiotides, Dimitrios-Dionysios Koutsouris. Multicentric assessment of cervical HPV infection co-factors in a large cohort of Greek women. European Journal of Gynaecological Oncology, 2020, 41(4): 545-555.

URL: 

https://ejgo.imrpress.com/EN/10.31083/j.ejgo.2020.04.5180     OR     https://ejgo.imrpress.com/EN/Y2020/V41/I4/545

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