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European Journal of Gynaecological Oncology  2020, Vol. 41 Issue (4): 500-503    DOI: 10.31083/j.ejgo.2020.04.5298
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An elderly patient with primary cervical CD5-positive diffuse large B-cell lymphoma: a case report and review of the literature
Gengrong Liu1, Zhenglei Shen1, Liefen Yin1, *(), Zhe Zhang2, Lingmei Yin2, Ke Wang2, Huan Yang2, Jin Yao2
1Department of Hematology, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, P. R. China
2Department of Hematology, Yunnan Tumor Hospital, Kunming, Yunnan, P. R. China
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Abstract  
Objective: To increase our understanding of the clinical features, diagnosis and treatment, and prognosis of primary cervical CD5+ diffuse large B-cell lymphoma (DLBCL) in an elderly patient. Materials and Methods: We analyzed a case of an elderly patient with primary cervical CD5+ DLBCL and reviewed the literature. Results: The clinical features of this patient were not specific and were manifested as fever, significantly elevated LDH, normal blood test results, an unidentified fraction (6.5%) of cells shown by bone marrow puncture, unexpressed T-system and medullary system markers, and a primary lesion of the cervix found upon positron emission tomography-computed tomography (PET-CT). Cervical biopsy plus immunohistochemical staining showed a CD5+DLBCL, and the diagnosis was confirmed and R-CHOP therapy achieved a favorable therapeutic effect. Conclusions: The clinical manifestations of primary cervical CD5+DLBCL are not specific but PET-CT combined with cervical biopsy can clarify the diagnosis with R-CHOPas the preferred therapeutic regimen.
Key words:  Elderly      Cervical      Diffuse large B cell lymphoma      CD5     
Submitted:  18 June 2019      Accepted:  08 August 2019      Published:  15 August 2020     
Fund: 
2017FE468(-204)/Applied Basic Research Joint Special and General Program of Yunnan Provincial Science and Technology Department
*Corresponding Author(s):  LIEFEN YIN     E-mail:  ylfynkm@126.com

Cite this article: 

Gengrong Liu, Zhenglei Shen, Liefen Yin, Zhe Zhang, Lingmei Yin, Ke Wang, Huan Yang, Jin Yao. An elderly patient with primary cervical CD5-positive diffuse large B-cell lymphoma: a case report and review of the literature. European Journal of Gynaecological Oncology, 2020, 41(4): 500-503.

URL: 

https://ejgo.imrpress.com/EN/10.31083/j.ejgo.2020.04.5298     OR     https://ejgo.imrpress.com/EN/Y2020/V41/I4/500

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