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European Journal of Gynaecological Oncology  2020, Vol. 41 Issue (4): 577-582    DOI: 10.31083/j.ejgo.2020.04.5457
Original Research Previous articles | Next articles
Evaluation of the effect of surgical timing on systemic response to trauma in premenopausal patients by using cytokine levels
Hayal Uzelli Şimşek1, *(), Turgay Şimşek2, Deniz Şahin3, Sertaç Ata Güler2, Nuh Zafer Cantürk2, Nihat Zafer Utkan2
1Department of Obstetrics and Gynaecology, Kocaeli University, Medical Faculty, Kocaeli, Turkey
2Department of General Surgery, Kocaeli University, Medical Faculty, Kocaeli, Turkey
3Department of Physiology, Kocaeli University, Medical Faculty, Kocaeli, Turkey
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Abstract  
Purpose: The aim of the study was to evaluate the severity of systemic responses to trauma; and thus, to determine the most advantageous timing for surgery among different phases of the menstrual cycle. Materials and Methods: 99 women were included in this study. They were patients who were in the postmenopausal period and patients in the different menstrual cycle phases of the premenopausal period. C-reactive protein, interleukin-1β, interleukin-6 and tumor necrosis factor-α levels were measured before and after surgery. Results: Among the menstrual cycle phases, the highest increases in the concentrations of IL-6 and TNF-α during the postoperative period were found in follicular phase patients. Luteal phase patients showed the lowest increases in interleukin-1β and interleukin-6 levels. TNF-α and CRP levels were increased significantly in all phases but not in the luteal phase. Conclusion: Timing of surgery in premenopausal patients seems effective on systemic inflammatory responses to trauma. Performing the operation based on the timing of the menstrual cycle will minimize the risk of operative trauma among premenopausal patients. This may be beneficial for their well-being.
Key words:  Breast cancer      Menstrual cycle      Surgery timing      Systemic responses to trauma     
Submitted:  22 December 2019      Accepted:  20 March 2019      Published:  15 August 2020     
*Corresponding Author(s):  HAYAL UZELLİ SIMSEK     E-mail:  jinekolog.dr@hotmail.com

Cite this article: 

Hayal Uzelli Şimşek, Turgay Şimşek, Deniz Şahin, Sertaç Ata Güler, Nuh Zafer Cantürk, Nihat Zafer Utkan. Evaluation of the effect of surgical timing on systemic response to trauma in premenopausal patients by using cytokine levels. European Journal of Gynaecological Oncology, 2020, 41(4): 577-582.

URL: 

https://ejgo.imrpress.com/EN/10.31083/j.ejgo.2020.04.5457     OR     https://ejgo.imrpress.com/EN/Y2020/V41/I4/577

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