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European Journal of Gynaecological Oncology  2021, Vol. 42 Issue (1): 148-153    DOI: 10.31083/j.ejgo.2021.01.2195
Original Research Previous articles | Next articles
Over expressions of neutrophil gelatinase-associated lipocalin and kidney injury molecule-1 in human uterine cervical neoplasms enhance tumor invasion
Dudu Solakoglu Kahraman1, Gulden Diniz2, *(), Sevil Sayhan1, Senem Ersavas3, Duygu Ayaz1, Elif Keskin4, Ibrahim Gulhan5
1Pathology Laboratory,SBU İzmir Tepecik Education and Research Hospital, 35020 Konak/İzmir, Turkey
2Pathology Department, İzmir Democracy University, 35140 Karabağlar/İzmir, Turkey
3Pathology Department, Akhisar Mustafa Kirazoglu State Hospital, Manisa, 45215 Akhisar/Manisa, Turkey
4Pathology Department, Edirne Trakya University, 22030 Edirne, Turkey
5Gynecologic Oncology Department, SBU İzmir Tepecik Education and Research Hospital, 35020 Konak/İzmir, Turkey
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Abstract  
Objective: Accumulating evidence has demonstrated upregulation of neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule-1 (KIM-1) in multiple malignancies which play a critical role in tumor progression. However, up to now little is known about the role played by NGAL in human uterine cervical carcinomas. In this retrospective study we aimed to evaluate the role of tissue expressions of NGAL and KIM-1 in a spectrum of uterine invasive and noninvasive cervical neoplasms. Methods: Immunohistochemical NGAL and KIM-1 expressions were investigated in a total of 107 formalin-fixed, paraffin-embedded uterine cervical tumor specimens and their association with different clinicopathologic parameters was evaluated. Results: In this series, cases with 30 low and 29 high- grade cervical squamous intraepithelial lesion (SIL), 27 squamous cell carcinoma (SCC), 15 adenosquamous carcinoma (ASC) and 6 adenocarcinoma (ACs) were detected. Positive NGAL expression was detected in only inflammatory cells of cases, whereas KIM-1 expression was detected in tumor cells. Statistically it was determined that the positivity rate of strong NGAL and KIM-1 expression was prominently higher in invasive carcinomas when compared with non-invasive squamous cell neoplasms (P < 0.01). KIM-1 expressions were not detected in any of the few cases with adenocarcinoma. Conclusion: Our findings have showed the presence of a correlation between membranous and cytoplasmic expressions of NGAL and KIM-1 and the invasive characteristics of uterine cervical neoplasms. As a result, expressions of NGAL and KIM-1 may be important in foreseeing the invasion and tumor progression.
Key words:  Adenosquamous carcinoma      Adenocarcinoma      Low- grade squamous intraepithelial lesions      High- grade squamous intraepithelial lesions      NGAL      KIM-1      Squamous cell carcinoma      Uterine cervix     
Submitted:  13 July 2020      Revised:  03 September 2020      Accepted:  14 September 2020      Published:  15 February 2021     
*Corresponding Author(s):  gulden.diniz@idu.edu.tr; agdiniz@gmail.com (Gulden Diniz)   

Cite this article: 

Dudu Solakoglu Kahraman, Gulden Diniz, Sevil Sayhan, Senem Ersavas, Duygu Ayaz, Elif Keskin, Ibrahim Gulhan. Over expressions of neutrophil gelatinase-associated lipocalin and kidney injury molecule-1 in human uterine cervical neoplasms enhance tumor invasion. European Journal of Gynaecological Oncology, 2021, 42(1): 148-153.

URL: 

https://ejgo.imrpress.com/EN/10.31083/j.ejgo.2021.01.2195     OR     https://ejgo.imrpress.com/EN/Y2021/V42/I1/148

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