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European Journal of Gynaecological Oncology  2020, Vol. 41 Issue (1): 42-47    DOI: 10.31083/j.ejgo.2020.01.4815
Original Research Previous articles | Next articles
Positive pelvic lymph node on [18F]-FDG PET is a prognostic factor in early-stage high-risk cervical cancer treated by radical hysterectomy and adjuvant chemoradiotherapy
D. Kim1, Y. Ki3, *(), W. Kim1, D. Park1, D. Suh2, K. Kim2, J. Lee3, H. Jeon3, J. Nam1
1 Departments of Radiation Oncology, Biomedical Research Institute, Pusan National University Hospital and Pusan National University School of Medicine, Busan, Korea
2 Departments of Obstetrics and Gynecology, Biomedical Research Institute, Pusan National University Hospital and Pusan National University School of Medicine, Busan, Korea
3 Department of Radiation Oncology, Pusan National University Yangsan Hospital and Pusan National University School of Medicine, Yangsan, Korea
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Abstract  
Purpose: The prognostic value of [18F]-fluorodeoxyglucose positron emission tomography (FDG PET) in early-stage high-risk cervical cancer patients was evaluated. Materials and Methods: A total of 86 Stage IB or IIA cervical cancer patients with high risk factors (positive resection margin (RM), parametrial invasion (PI) or pelvic lymph node (PLN) metastasis) were retrospectively investigated. Results: There was a statistically significant decrease in recurrence-free survival (RFS) in patients with bulky tumor (p = 0.011), positive RM (p = 0.001), and PLN positivity on FDG PET (p = 0.012) in multivariate analyses. Independent prognostic factors for overall survival (OS) included non-squamous cell type (p = 0.005), bulky tumor (p = 0.020), and PLN positivity on FDG PET (p = 0.007). Patients with positive PLN on FDG PET had worse five-year RFS (62.0% vs. 85.0%, p = 0.013) and OS (68.7% vs. 89.5%, p = 0.011) rates than those with negative PLN uptake. Conclusion: PLN metastasis on FDG PET and bulky tumor were found to be statistically significant prognostic factors for both RFS and OS in early-stage high-risk cervical cancer patients.
Key words:  Cervical cancer      High risk factors      Adjuvant chemoradiotherapy      FDG PET     
Published:  15 February 2020     
Fund: 
Pusan National University Hospital
*Corresponding Author(s):  YONGKAN KI     E-mail:  apex7171@hanmail.net

Cite this article: 

D. Kim, Y. Ki, W. Kim, D. Park, D. Suh, K. Kim, J. Lee, H. Jeon, J. Nam. Positive pelvic lymph node on [18F]-FDG PET is a prognostic factor in early-stage high-risk cervical cancer treated by radical hysterectomy and adjuvant chemoradiotherapy. European Journal of Gynaecological Oncology, 2020, 41(1): 42-47.

URL: 

https://ejgo.imrpress.com/EN/10.31083/j.ejgo.2020.01.4815     OR     https://ejgo.imrpress.com/EN/Y2020/V41/I1/42

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