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European Journal of Gynaecological Oncology  2020, Vol. 41 Issue (4): 556-562    DOI: 10.31083/j.ejgo.2020.04.5076
Original Research Previous articles | Next articles
Transmembrane G protein–coupled receptor 30 (GPR30) gene polymorphisms in Korean Women with Ovarian Cancer: An experimental study
Ji Young Park1, Gun Oh Chong2, Yoon Hee Lee2, Hyun Jung Lee2, Chul Min Park3, Eun Hye Lee1, Dae Gy Hong2, *()
1Department of Pathology, School of Medicine, Kyungpook National University, Daegu, Republic of Korea
2Department of Obstetrics and Gynecology, School of Medicine, Kyungpook National University, Daegu, Republic of Korea
3Department of Obstetrics and Gynecology, School of Medicine, Jeju National University, Jeju, Republic of Korea
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Abstract  
Purpose: To compare genetic distribution of fourteen (14) G protein–coupled receptor 30 (GPR30) single-nucleotide polymorphisms (SNPs) in patients with ovarian cancer or benign gynecological disease. Materials and Methods: We examined 117 Korean females with postoperative specimens available for DNA extraction. We used predesigned PCR/Sanger or Sequencing Primer and TaqMan®SNP Genotyping Assays for SNP genotyping of the GPR30 gene and performed immunohistochemical staining for assessing GPR30 protein expression. We analyzed linkage disequilibrium (LD) and evaluated differences in genotype and allele frequency between the two groups. Results: We observed no differences in genotype distribution and allele frequency between the two groups. Two LD blocks were determined in both groups. All specimens of both groups revealed intensive staining with a high percentage of positive cells exhibiting GPR30 expression. Conclusions: This study could not demonstrate differences in the genetic distribution of fourteen GPR30 gene polymorphisms in Korean women with ovarian cancer and disease-free controls.
Key words:  cancer      G protein–coupled receptor 30      single-nucleotide polymorphism      Korean     
Submitted:  19 November 2018      Accepted:  28 January 2019      Published:  15 August 2020     
Fund: 
Biomedical Research Institute grant from Kyungpook National University Hospital
*Corresponding Author(s):  DAE GY HONG     E-mail:  chssa0220@hanmail.net

Cite this article: 

Ji Young Park, Gun Oh Chong, Yoon Hee Lee, Hyun Jung Lee, Chul Min Park, Eun Hye Lee, Dae Gy Hong. Transmembrane G protein–coupled receptor 30 (GPR30) gene polymorphisms in Korean Women with Ovarian Cancer: An experimental study. European Journal of Gynaecological Oncology, 2020, 41(4): 556-562.

URL: 

https://ejgo.imrpress.com/EN/10.31083/j.ejgo.2020.04.5076     OR     https://ejgo.imrpress.com/EN/Y2020/V41/I4/556

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