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European Journal of Gynaecological Oncology  2020, Vol. 41 Issue (6): 913-918    DOI: 10.31083/j.ejgo.2020.06.2107
Original Research Previous articles | Next articles
Lymphoepithelioma-like carcinoma of the uterine cervix: correlation with Epstein-Barr virus and human papillomavirus infection. A single-center experience
Angel Yordanov1, , *(), Ivan Ivanov2, Tereza Dineva3, Sаvelina Popovska2, Milena Karcheva4, Strahil Strashilov5, Stoyan Kostov6, Stanislav Slavchev6, Assia Konsoulova7, Mariela Vasileva-Slaveva8, 9, 10,
1Department of Gynecologic Oncology, Medical University Pleven, 5800 Pleven, Bulgaria
2Department of General and Clinical Pathology, Medical University-Pleven, 5800 Pleven, Bulgaria
3Scientific Laboratory, Department of Epidemiology, Medical University Pleven, 5800 Pleven, Bulgaria
4Department of Epidemiology, Medical University-Pleven, 5800 Pleven, Bulgaria
5Department of Plastic and Reconstructive Surgery, MU-Pleven, 5800 Pleven, Bulgaria
6Department of Gynecology, Medical University Varna, 9000 Varna, Bulgaria
7Complex Oncological Center Burgas, 8000 Burgas, Bulgaria
8EXTRO-Lab, Department of Therapeutic Radiology and Oncology, Medical University of Innsbruck, 6020 Innsbruck, Austria
9Tyrolean Cancer Research Institute, 6020 Innsbruck, Austria
10EORTC Pathobiology Group, 1200 Brussels, Belgium
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Abstract  
Background and objectives: Lymphoepithelioma-like carcinoma of the uterine cervix (LELC) is a rare subtype of the squamous cell carcinoma with unclear viral carcinogenesis and prognosis. Aim: We aimed to investigate the status of HPV and EBV infection in a cohort of Caucasian women with LELC of the uterine cervix and to compare the results on prevalence, association with both viruses and methods of detection in this disease with the results of other studies. Materials and methods: We retrospectively evaluated all patients with LELC, diagnosed and treated at Department of Gynaecologic Oncology, Medical University Pleven, Bulgaria between 2008 and 2015. The status of infection with HPV and EBV was investigated on tumor tissue by polymerase chain reaction (PCR) and in situ hybridization (ISH). We compare the results with the results from a systematic search of the literature on this topic. Results: LELCs represented 3.03% (16 patients) of all stage I cervical carcinoma cases. Infection with HPV and EBV was investigated in 50% (8) of them. ISH and PCR testing detected HPV in 37.5% (3) and 50% (4) of the patients; EBV in 12.5% (1) and 75% (6). No cases of co-infection were found with ISH and 4 with PCR. In the literature are reported 98 cases of this disease and infection with EBV is found in 25.7% the tested patients. Conclusion: HPV and EBV strains and a co-infection of the two viruses are possible factors in genesis of LELC of the uterine cervix. Our data suggests that infection with EBV could be more common in Caucasians women with LELC, than previously reported.
Key words:  Cervical cancer      Lymphoepithelioma-like carcinoma      Epstein-Barr virus      Human papillomavirus      In situ hybridization      Polymerase chain reaction     
Submitted:  12 April 2020      Accepted:  09 June 2020      Published:  15 December 2020     
Fund: 
Medical University Pleven
*Corresponding Author(s):  ANGEL DANCHEV YORDANOV     E-mail:  angel.jordanov@gmail.com
About author:  Contributed equally.

Cite this article: 

Angel Yordanov, Ivan Ivanov, Tereza Dineva, Sаvelina Popovska, Milena Karcheva, Strahil Strashilov, Stoyan Kostov, Stanislav Slavchev, Assia Konsoulova, Mariela Vasileva-Slaveva. Lymphoepithelioma-like carcinoma of the uterine cervix: correlation with Epstein-Barr virus and human papillomavirus infection. A single-center experience. European Journal of Gynaecological Oncology, 2020, 41(6): 913-918.

URL: 

https://ejgo.imrpress.com/EN/10.31083/j.ejgo.2020.06.2107     OR     https://ejgo.imrpress.com/EN/Y2020/V41/I6/913

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