Special Issues

Special Issue Title: Immunotherapy for Gynecological Oncology

· Print Special Issue Flyer

· Deadline for manuscript submissions:  31 July 2021


Special Issue Editor

Guest Editor


Prof. Dr. Tadahiro Shoji

Department of Obstetrics and Gynecology, Iwate Medical University School of Medicine, Japan

Website | E-Mail

Interests: Ovarian Cancer


Special Issue Information

Dear Colleagues,


In recent years, immunotherapy has been studied as a promising candidate for being the "fourth pillar" in the treatment of gynecological cancer. Unfortunately, however, no cancer vaccine therapy targeting tumor-specific antigens has yet been approved in any field, including the field of gynecological cancer, and progress in the development of such therapies has been slow. In contrast, recently developed immune checkpoint inhibitors, such as anti-cytotoxic T-lymphocyte antigen 4 antibodies and anti-programmed cell death 1 antibodies, have attracted attention because of their dramatic and long-term antitumor effects and have vitalized the development of cancer immunotherapies.

The response rates to immune checkpoint inhibitors are estimated to be up to 30% for melanoma and approximately 10%–20% for other types of cancer, except for Hodgkin's lymphoma. These drugs are expensive and may cause autoimmune adverse events. Future issues related to immune checkpoint inhibitor therapy include the selection of responders, identification of biomarkers useful for determining the optimal treatment duration and other treatment details in responders, and development of therapies for patients who do not respond to immune checkpoint inhibitors.

At present, in the field of gynecology, studies are being conducted to evaluate combinations of multiple cancer immunotherapies and combinations of cancer immunotherapy with chemotherapy, molecular-targeted drugs, or other treatments. Furthermore, personalized peptide vaccine therapy and personalized T-cell transfer therapy based on tumor-specific mutant antigens have been studied in some cancer types and histological types associated with various gene mutations. Thus, cancer immunotherapy can be regarded as a promising therapy in the field of gynecology.

The aim of this special issue of the Journal is to collect new insights on this fascinating topic.


Prof. Dr. Tadahiro Shoji

Guest Editor

 

Manuscript Submission Information

Manuscripts should be submitted online at https://ejgo.imrpress.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. European Journal of Gynaecological Oncology is an international peer-reviewed open access quarterly journal published by IMR Press.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is $1250. Submitted papers should be well formatted and use good English.


Keywords

Cancer Immunotherapy; Cancer Vaccination; Immune Checkpoint Inhibitor; Ovarian Cancer; Cervical Cancer; Endometrial Cancer


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Treatment strategies for ovarian cancer focusing on prostaglandins
Tatsuhiko Shigeto, Yoshihito Yokoyama
European Journal of Gynaecological Oncology    2021, 42 (5): 996-1000.   DOI: 10.31083/j.ejgo4205148
Abstract87)   HTML5)    PDF(pc) (490KB)(33)       Save

This work aims to researching the potential of anti-inflammatory therapy as an adjuvant in the antiblastic treatment for ovarian cancers. Drugs commonly used for dyslipidemia and diabetes mellitus and anti-inflammatory drugs have tumor-suppressing effects via anti-angiogenic and apoptosis-inducing actions. Proinflammatory prostaglandins (PGs) promote angiogenesis and suppress apoptosis. A therapeutic agent for dyslipidemia, Clofibric acid increases carbonyl reductase 1 (CBR1), which inactivates PGs in the tumor, and exerts a tumor shrinkage effect. Oral hypoglycemic agents, ciglitazone and pioglitazone reduce PG synthase and cyclooxygenase (COX) 2 in tumors and shrink them. A selective COX-2 inhibitor, Meloxicam directly inhibits PG production and shrinks tumors. These facts remind us of the importance of drug repositioning. Considering that the safety has been established including side effects, these drugs have the potential to be used not only to treat ovarian cancer but also human solid cancers in general as a combination adjuvant drug with other anticancer agents or to be applied to tumor dormancy therapy with different properties from anticancer agents.
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Characteristics of microsatellite instability-high gynecologic cancer and efficacy of pembrolizumab: a single-institution experience
Tomoko Sakamoto Taniguchi, Shinichi Komiyama, Masaru Nagashima, Mineto Morita
European Journal of Gynaecological Oncology    2021, 42 (4): 752-756.   DOI: 10.31083/j.ejgo4204113
Abstract215)   HTML110)    PDF(pc) (588KB)(164)       Save

Objective: The aim of this study was to examine the frequency and characteristics of patients with gynecologic cancer with microsatellite instability (MSI)-high, as well as the efficacy of pembrolizumab in these patients, by reviewing the experience of a single institution that performs MSI testing. Methods: We retrospectively investigated the frequency and characteristics of MSI-high in patients with advanced or recurrent gynecologic cancer who underwent MSI testing at Toho University Omori Medical Center. As MSI testing, the distribution of microsatellite length at five microsatellite markers (BAT25, BAT26, NR21, NR24, and MONO27) was analyzed by multiplex polymerase chain reaction. We considered to be MSI-high if two or more microsatellite markers were positive. Among patients with MSI-high, we investigated the clinical course of those who received pembrolizumab. Results: MSI testing was performed on 51 patients, four of whom (7.8%) showed MSI-high. Two of the four patients had recurrent endometrial cancer (poorly differentiated endometrioid in one and moderate differentiated endometrioid + clear cell + serous in the other), one had advanced endometrial cancer (stage IVB, poorly differentiated endometrioid), and one had advanced ovarian cancer (stage IIIC, clear cell). No MSI-high was found in the other gynecological cancers. The rate of MSI-high was 15.0% (3/20) for endometrial cancer and 6.7% (1/15) for ovarian cancer. Of the four patients with MSI-high, two received pembrolizumab monotherapy. Both of these patients responded well and have maintained the response for more than 12 months. Discussion: This is the first real-world study investigating MSI-high in Japanese women with gynecologic cancer. MSI testing should be performed aggressively in clinical practice to identify patients with advanced and recurrent gynecologic cancers who can benefit from pembrolizumab.

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