Special Issues

Special Issue Title: Hyperthermic Intraperitoneal Chemotherapy to Gynaecological Oncology

· Print Special Issue Flyer

· Deadline for manuscript submissions: 30 June 2021

Special Issue Editor

Guest Editor

Prof. Dr. Christos Iavazzo

Gynaecological Oncology Department - Metaxa Cancer Hospital, Piraeus, Greece

Interests: Gynaecological Oncology, HIPEC, Robotic and Laparoscopic Surgery

Dr Victoria Psomiadou

Gynaecological Oncology Department - Metaxa Cancer Hospital, Piraeus, Greece

Interests: Oncology; Obstetrics; Gynaecology

Dr Anastasia Prodromidou

Clinic of Gynecological Oncology, Metaxa Memorial Cancer Hospital, Piraeus, Greece

Interests: Gynaecology; Obstetrics; Pediatrics

Dr. Alexandros Fotiou

Gynaecological Oncology Department - Metaxa Cancer Hospital, Piraeus, Greece

Interests: Cancer; Cancer Diagnostics; Tumor Biology; Cancer Metastasis; Tumor Markers

Special Issue Information

Dear Colleagues,

The role of hyperthermic intraperitoneal chemotherapy (HIPEC) as a standard treatment procedure in the field of gynecologic oncology is controversial. Although widely discussed and studied as a subsidiary method of interval cytoreductive surgery, HIPEC remains debatable even in the management of advanced and recurrent epithelial ovarian cancer. Hence, many large trials support the safety and efficacy of the method regarding the extension of overall survival in well selected EOC patients. Interestingly, encouraging findings support the effectiveness of HIPEC even performed at the time of primary debulking surgery in stage III EOC patients, by whom a complete cytoreduction is anticipated, and large ongoing trials’ results will be shortly available. The promising results of studies investigating HIPEC combined with adjuvant chemotherapy with platinum compounds in the management of advanced stage peritoneal disseminated endometrial and cervical cancer add to recent evidence and verify further more thorough research. Remarkably, peritoneal carcinomatosis from non-gynecological origin in patients with abdominally confined disease has been considered an indication for hyperthermic intraperitoneal chemotherapy. Originally in cases of pseudomyxoma peritonei and malignant peritoneal mesothelioma followed by gastric, colorectal and even breast cancer patients with pelvic peritoneal metastases, many authors have published supporting data about explorative surgery followed by cytoreduction and HIPEC.

Nevertheless, more prospective multi-center randomized studies need to be designed in order to draw safe conclusions and determine which patients could benefit from the implementation of this approach. Further issues to be determined encompass robust data of the surgical procedures, the art and dose of chemotherapeutic regimens as well as the temperature and duration of the hyperthermic arm that will warrant the optimal oncological outcome and support the recommendation of HIPEC by the gynecological cancer community.

The aim of our special issue is to publish interesting studies in the field exploring the indications, technique, future challenges. We welcome authors to submit case reports, case series, retrospective studies, randomized trials and reviews regarding the role of HIPEC in different gynecological cancers.

Prof. Dr. Christos Iavazzo, Dr. Alexandros Fotiou, Alexandros Fotiou, and Dr. Anastasia Prodromidou

Guest Editor


Manuscript Submission Information

Manuscripts should be submitted online at https://ejgo.imrpress.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Clinical Experimental Obstetrics and Gynecology is an international peer-reviewed open access quarterly journal published by IMR Press.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is $1250. We normally offer a discount greater than 30% (APC: $850) to all contributors invited by the Editor-in-Chief, Guest Editor (GE) and Editorial board member. Submitted papers should be well formatted and use good English.


Gynecologic Cancer; hysteroscopy; cancer prevention; early diagnosis; cancer screening; pre-operative cancer workup

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Planned Papers

Type: Original Research
Title:  Eliminating tumor cell entrapment from the natural history of gynecologic malignancy
Authors: Paul H. Sugarbaker

Type: Review
Title:  Pharmacological considerations in hyperthermic intraperitoneal chemotherapy for ovarian cancer
Authors: Eelco de Bree

Type: Case Report
Title:  CRS and HIPEC in a patient with recurrent ovarian cancer after primary debulking surgery and adjuvant chemotherapy, a case report and MDT discussion
Authors: Alexandros Fotiou

Type: Systematic Review
Title:  Cost effectiveness analysis of cytoreductive surgery plus HIPEC for advanced ovarian cancer treatment, a systematic review of the literature
Authors: Alexandros Fotiou

Type: Review
Title:  Is minimal invasive surgical treatment of ovarian cancer plus HIPEC a utopia? A review of the literature
Authors: Alexandros Fotiou

Type: Review
Title:  Pressurized intraperitoneal aerosol chemotherapy (PIPAC) in treatment of advanced ovarian cancer. A review of the literature
Authors: Alexandros Fotiou

Type: Original Research
Title:  HIPEC use in ovarian cancer patients, a promising alternative treatment in experienced tertiary centers
Authors: Alexandros Fotiou

Type: Case Report
Title:  Debulking surgery and HIPEC in a recurrent Ovarian Granulosa Tumor
Authors: Theo Panoskaltsis

Type: Original Research
Title:  Cytoreductive surgery and HIPEC in gynecological oncology in a high volume center in Romania
Authors: Bogdan Moldovan

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